Synthetic epigenetic memory
نویسندگان
چکیده
منابع مشابه
Synthetic reversal of epigenetic silencing.
Controlling cell fate-determining gene expression is key to stem cell differentiation, tissue regeneration, and cancer therapy. To date, custom-built transcription factors recognize the information encoded in specific DNA sequences. Chromatin proteins undergo covalent modifications and form complexes that encode a second layer of information that determines proximal gene activity. Here, we empl...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2017
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth.4382